Intense exercise can suppress appetite

Exercising can cure your appetite! Intense exercise can activate molecules that stave off hunger, new study finds

  • Researchers have found that intense exercise can have an appetite suppressant effect
  • They discovered the molecule lac-phe, which appears in the blood after exercise
  • When given to overly obese mice, the molecule causes them to eat less and lose weight over a ten-day period
  • The researchers hope that after more research, the molecule could be used at the center of weight loss strategies in the future.

Intense workouts can help cut calories in two different ways, according to a new study that has found that exercise can actually activate molecules in the body that suppress hunger in addition to burning calories.

Researchers at Stanford University in the Bay Areas have discovered what they describe as an “anti-hunger” molecule that reduces the appetite of animals after they exercise.

When isolating the molecule and administering it to an animal, it also helped reduce appetite and overall weight gain.

Researchers hope the molecule could be used centrally in weight loss supplements in the future, and until then weight-conscious people can keep this benefit of exercise in mind when planning a diet. future programs.

Researchers have found that exercise leads to the activation of a molecule called lac-phe, which suppresses appetite and leads to better blood sugar control (file photo)

“We are all generally aware that exercise is beneficial. It’s good for body weight and blood sugar control,’ said Stanford assistant professor of pathology Dr. Jonathan Long in a university outing.

“But we wanted to look at this concept in more detail – we wanted to see if we could dissect exercise in terms of molecules and pathways.”

The researchers, who published their findings last week in nature, first conducted trials on mice to see how they would respond to exercise at the molecular level.

Long, who led the research, began his research with the explicit goal of trying to learn something new about metabolomics – the study of small metabolites in a person’s body.

To do this, they ran a group of mice on a treadmill before measuring the peaks of certain molecules in their blood.

There are hundreds, if not thousands, of molecules activating in the blood all the time, but one caught their attention Lac-Phe, a combination of lactate and phenylalanine.

The researchers then isolated the molecule and gave it to mice with diet-induced obesity to see how it would affect their appetite.

Over the next 12 hours, the induced mice ate 50% less than usual.

Stanford assistant professor of pathology Dr Jonathan Long (pictured) said his team began the research with an interest in finding something, anything, new

Stanford assistant professor of pathology Dr Jonathan Long (pictured) said his team began the research with an interest in finding something, anything, new

After ten days of using the substance, the mice’s total food intake and body weight had dropped.

The mice were also more tolerant to glucose – a sign that the molecule also has effective effects against diabetes.

Long and his team then traveled to the California racetrack to test their findings on larger animals.

They found that racehorses also produce the compound after running. Further examination revealed that humans also generate the molecule.

“We estimate that the lac-phe pathway is responsible for approximately 25% of the anti-obesity effects of exercise,” Long said.

Although the research is still in its early stages and it may still be some time before the molecule is used in weight loss supplements, Long hopes this is the start of groundbreaking research in the field. of weight loss.

It also comes at a necessary time, as America suffers from an obesity crisis. More than half of Americans are overweight, according to official figures, of which more than 40% suffer from obesity.


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